Treatment of Diabetic Foot Infections: Infections of the bone (osteomyelitis) after failure of antibiotics and appropriate surgical care. For such patients, the standard treatment is amputation but we have demonstrated that such infections can be treated with phage and the need for amputation greatly reduced.
C. difficile Infection and Antibiotic Resistance: Phage are critical to the problem of antibiotic resistance and the dysbiosis that leads to infection with C. difficile and other multi drug resistant organisms (MDROs).
Phage in the gut microbiome: Patients treated with fecal transplant for recurrent C. difficile Infection. In this case the “phage therapy” is in the form of the fecal Microbiota Transplant (FMT).